The protein encoded by this gene is member of the GAP1
family of GTPase-activating proteins. These proteins stimulate the
GTPase activity of normal RAS p21 but not its oncogenic
counterpart. Acting as a suppressor of RAS function, the protein
enhances the weak intrinsic GTPase activity of RAS proteins
resulting in the inactive GDP-bound form of RAS, thereby allowing
control of cellular proliferation and differentiation. This
particular family member contains domains which are characteristic
of the GAP1 subfamily of RasGAP proteins but, in contrast to the
other GAP1 family members, this protein is strongly and selectively
expressed in endocrine tissues. Alternatively spliced transcript
variants that encode different isoforms have been described1) Ohta, M., et al. Gastroenterology 136(1):206-216(2009)
Immunogen
This RASAL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 309-337 amino acids from the Central region of human RASAL1.
Western blot analysis in mouse liver tissue lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.