RNA-binding protein 28, RNA-binding motif protein 28, RBM28
Product description
The protein encoded by this gene is a specific nucleolar
component of the spliceosomal small nuclear ribonucleoprotein
(snRNP)complexes . It specifically associates with U1, U2, U4, U5,
and U6 small nuclear RNAs (snRNAs), possibly coordinating their
transition through the nucleolus. Mutation in this gene causes
alopecia, progressive neurological defects, and endocrinopathy (ANE
syndrome), a pleiotropic and clinically heterogeneous disorder.
Alternatively spliced transcript variants encoding different
isoforms have been found for this gene.1) Spiegel, R., et al. Eur. J. Endocrinol. 162(6):1021-1025(2010)
Immunogen
This RBM28 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 62-91 amino acids from the N-terminal region of human RBM28.
Western blot analysis in MCF-7 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.