Application
Immunohistochemistry staining of Retinoic Acid receptor alpha in breast tissue using Retinoic Acid receptor alpha Antibody.| Product Name | Retinoic Acid Receptor alpha Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | RARA, NR1B1, PML-RAR, RAR-alpha, RARalpha, Retinoic acid receptor alpha, Pml-rara, RAR, RAR alpha, Retinoic acid receptor, alpha |
| Product description | Retinoic acid receptor alpha (RAR alpha), a NR1 Thyroid Hormone-Like Receptor, has a key effect on the development of acute promyelocytic leukemia (APL). APL results from chromosomal translocation of RAR alpha to various partner genes, including the promyelocytic leukemia (PML) gene on 15q22, the promyelocytic leukemia zinc finger (PLZF) gene on 11q23, the nucleophosmin (NPM) gene on 5q35, the nuclear mitotic apparatus (NuMA) gene on 11q13, and the signal transducer and activator of transcription STAT5b. The aberrant RAR alpha fusion proteins contribute to leukemic transformation by dominant inhibition of the expression of target genes that are important for cellular differentiation. Four alternatively spliced isoforms of RAR alpha have been documented in humans (RAR alpha1, RAR alpha2, RAR alpha1DeltaBC, and RAR alpha1DeltaB), one of which, RAR alpha1DeltaB, does not code for a functional receptor. |
| Immunogen | Retinoic Acid Receptor alpha antibody was raised against recombinant (partial), N-Terminal amino acids 1 - 100 region of Retinoic Acid Receptor alpha (Human). |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| Retinoic Acid Receptor alpha antibody can be used in ELISA starting at 1:100 - 1:500, Western Blot, and immunohistochemistry starting at 10 μg/mL.: |
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| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | RARA |
|---|---|
| Alternative Names | RARA NR1B1 PML-RAR RAR-alpha RARalpha Retinoic acid receptor alpha Pml-rara RAR RAR alpha Retinoic acid receptor alpha |
Application
Immunohistochemistry staining of Retinoic Acid receptor alpha in breast tissue using Retinoic Acid receptor alpha Antibody.| Application Notes | Retinoic Acid Receptor alpha antibody can be used in ELISA starting at 1:100 - 1:500, Western Blot, and immunohistochemistry starting at 10 μg/mL.: |
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| Form | Liquid |
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| Storage Instructions | Store Retinoic Acid Receptor alpha antibody at -20 ˚C. Aliquot to avoid freeze/thaw cycles. |
| Storage Buffer | Phosphate-buffered solution, pH 7.2, 0.09% sodium azide, 50% glycerol. |
