Application
Western blot of hippocampal lysate showing specific immunolabeling of the ~48k RAR-alpha protein.| Product Name | Retinoic Acid Receptor Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | RAR, NR1B1, Nuclear receptor subfamily 1 group B member 1, RAR-alpha |
| Product description | Retinoic acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The retinoid X receptors (RXRs) family (RXRalpha, beta and gamma), preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005).1) Abu J, Batuwangala M, Herbert K, Symonds P (2005) Retinoic acid and retinoid receptors: potential chemopreventive and therapeutic role in cervical cancer. Lancet Oncol 6:712-720. |
| Immunogen | Peptide corresponding to amino acid residues from the N-terminal region of human retinoic acid receptor, a-isotype. |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1 |
| Host Species | Mouse |
| Tested Applications | WB |
| The antibody has been directly tested for reactivity in Western blots in human tissues. It is anticipated that the antibody will also work with bovine, canine and mouse tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen.: |
|
| Species Reactivity | BovineDogHumanMouse |
| Concentration | 1mg/ml |
| Purification | Protein G |
| Gene Symbol | RARA |
|---|---|
| Alternative Names | RAR NR1B1 Nuclear receptor subfamily 1 group B member 1 RAR-alpha |
| Molecular Weight(MW) | 48 |
Application
Western blot of hippocampal lysate showing specific immunolabeling of the ~48k RAR-alpha protein.| Application Notes | The antibody has been directly tested for reactivity in Western blots in human tissues. It is anticipated that the antibody will also work with bovine, canine and mouse tissues based on the fact that these species have 100% homology with the amino acid sequence used as antigen.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Retinoic Acid Receptor antibody can be stored at -20˚C and is stable at -20˚C for at least 1 year. |
| Storage Buffer | 100 uL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per mL BSA and 50% glycerol. |
