Retinoic acid receptor beta (RAR beta), a NR1 Thyroid Hormone-Like Receptor, is involved in the regulation of cell growth, differentiation, apoptosis, and carcinogenesis. RAR beta forms heterodimers with the retinoic acid X receptor (RXR) and binds to the direct repeat 1 (DR1) sequence of target DNA. A growing body of evidence supports the hypothesis that RAR beta is a tumor-suppressor gene. Altered expression of RAR beta has been linked to cancers, including those of the head and neck, lung, esophagus, breast, pancreas, and cervix. Three isoforms of RAR beta, beta 1, beta 2, and beta 4, have been documented in humans.
Immunogen
Retinoic Acid Receptor beta antibody was raised against a peptide located near the C-Terminal region of Retinoic Acid Receptor beta (Human).
Key Feature
Clonality
Polyclonal
Host Species
Rabbit
Tested Applications
ELISAIHC
Retinoic Acid Receptor beta antibody can be used in immunohistochemistry starting at 10 - 15 μg/mL.:
Immunohistochemistry staining of Retinoic Acid receptor beta in intermediate trophoblasts tissue using Retinoic Acid receptor beta Antibody.
Application Notes
Retinoic Acid Receptor beta antibody can be used in immunohistochemistry starting at 10 - 15 μg/mL.:
Additional Information
Form
Liquid
Storage Instructions
Retinoic Acid Receptor beta antibody should be stored long term (months) at -80 ˚C and short term (days) at 4 ˚C. As with all antibodies avoid freeze/thaw cycles.