Application
Immunohistochemistry staining of RFFL in brain cortex tissue using RFFL Antibody.| Product Name | RFFL Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | RFFL, CARP2, Caspase regulator CARP2, FRING, RIFIFYLIN, RNF189, RNF34L, RING finger protein 34-like, CARP-2, RING finger protein 189 |
| Product description | RFFL, also known as Rififylin, RING finger and FYVE-like domain-containing protein 1, FYVE-RING finger protein, Sakura, Fring, Caspases-8 and -10-associated RING finger protein 2, CARP-2, Caspase regulator CARP2, RING finger protein 189 and RING finger protein 34-like, is a novel modulator of NF-κB activation. RFFL possesses E3 ubiquitin protein ligase activity and has been shown to regulate the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. RFFL also possesses anti-apoptotic activity and may bind phosphatidylinositol phosphates. RFFL is a membrane bound cytoplasmic protein that is expressed ubiquitously. RFFL can be detected in spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes and is rapidly degraded after stimulation with TNFSF10, and probably by caspases. Multiple transcript variants have been detected for this protein. |
| Immunogen | RFFL antibody was raised against amino acids from the C-Terminus of RFFL (Human) Amino acids 1-363. |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHCWB |
| RFFL antibody can be used in ELISA starting at 1 μg/mL, Western Blot starting at 1 μg/mL, and immunohistochemistry starting at 5 μg/mL.: |
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| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | RFFL |
|---|---|
| Alternative Names | RFFL CARP2 Caspase regulator CARP2 FRING RIFIFYLIN RNF189 RNF34L RING finger protein 34-like CARP-2 RING finger protein 189 |
Application
Immunohistochemistry staining of RFFL in brain cortex tissue using RFFL Antibody.| Application Notes | RFFL antibody can be used in ELISA starting at 1 μg/mL, Western Blot starting at 1 μg/mL, and immunohistochemistry starting at 5 μg/mL.: |
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| Form | Liquid |
|---|---|
| Storage Instructions | Store RFFL antibody at 4 ˚C or -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide. |
