The protein encoded by this gene is a member of the
regulator of G protein signaling (RGS) family. RGS family members
share similarity with S. cerevisiae SST2 and C. elegans egl-10
proteins, which contain a characteristic conserved RGS domain. RGS
proteins accelerate GTPase activity of G protein alpha-subunits,
thereby driving G protein into their inactive GDP-bound form, thus
negatively regulating G protein signaling. RGS proteins have been
implicated in the fine tuning of a variety of cellular events in
response to G protein-coupled receptor activation. The biological
function of this gene, however, is unknown. Two transcript variants
encoding the same isoform exist.1) Wang, J., et al. Carcinogenesis 31(10):1755-1761(2010)
Immunogen
This RGS13 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 61-90 amino acids from the Central region of human RGS13.
Western blot analysis in 293 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.