Blood group Rh(D) polypeptide, RHXIII, Rh polypeptide 2, RhPII, Rhesus D antigen, CD240D, RHD
Product description
The Rh blood group system is the second most clinically
significant of the blood groups, second only to ABO. It is also the
most polymorphic of the blood groups, with variations due to
deletions, gene conversions, and missense mutations. The Rh blood
group includes this gene, which encodes the RhD protein, and a
second gene that encodes both the RhC and RhE antigens on a single
polypeptide. The two genes, and a third unrelated gene, are found
in a cluster on chromosome 1. The classification of Rh-positive and
Rh-negative individuals is determined by the presence or absence of
the highly immunogenic RhD protein on the surface of erythrocytes.
Multiple transcript variants encoding different isoforms have been
found for this gene.1) Flegr, J., et al. Folia Parasitol. 57(2):143-150(2010)
Immunogen
This RHD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 173-201 amino acids from the Central region of human RHD.
Western blot analysis in A549 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.