Unconventional prefoldin RPB5 interactor 1, Protein NNX3, Protein phosphatase 1 regulatory subunit 19, RNA polymerase II subunit 5-mediating protein, RPB5-mediating protein, URI1, C19orf2, NNX3, PPP1R19, RMP, URI
Product description
The protein encoded by this gene binds to RNA polymerase II subunit 5 (RPB5) and negatively modulates transcription through its binding to RPB5. The encoded protein seems to have inhibitory effects on various types of activated transcription, but it requires the RPB5-binding region. This protein acts as a corepressor. It is suggested that it may require signaling processes for its function or that it negatively modulates genes in the chromatin structure. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.1) Delgermaa, L., et al., Mol. Cell. Biol. 24(19):8556-8566 (2004).
Immunogen
This RMP (URI) antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 347-376 amino acids from the C-terminal region of human RMP (URI).
Unconventional prefoldin RPB5 interactor 1 Protein NNX3 Protein phosphatase 1 regulatory subunit 19 RNA polymerase II subunit 5-mediating protein RPB5-mediating protein URI1 C19orf2 NNX3 PPP1R19 RMP URI
Antibody is used in Western blot to detect RMP in T47D (left) and Jurkat (right) cell line lysates.
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.