Ribonuclease pancreatic, HP-RNase, RIB-1, RNase UpI-1, Ribonuclease 1, RNase 1, Ribonuclease A, RNase A, RNASE1, RIB1, RNS1
Product description
This gene encodes a member of the pancreatic-type of
secretory ribonucleases, a subset of the ribonuclease A
superfamily. The encoded endonuclease cleaves internal
phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It
prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic
nucleotides, with a pH optimum near 8.0. The encoded protein is
monomeric and more commonly acts to degrade ds-RNA over ss-RNA.
Alternative splicing occurs at this locus and four transcript
variants encoding the same protein have been identified. [provided
by RefSeq].1) D'Alessio, G. Biopolymers 91(12):989-994(2009)
Immunogen
This RNASE1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 14-42 amino acids from the N-terminal region of human RNASE1.
Western blot analysis in MDA-MB453 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.