COPII-coated vesicles are involved in protein transport
from the endoplasmic reticulum to the Golgi apparatus. The protein
encoded by this gene was identified by its interaction with a mouse
protein similar to yeast Sec23p, an essential component of the
COPII. This protein shares significant similarity with
phospholipid-modifying proteins, especially phosphatidic acid
preferring-phospholipase A1. Overexpression of this protein has
been shown to cause disorganization of the endoplasmic
reticulum-Golgi intermediate compartment and Golgi apparatus, which
suggests its role in the early secretory pathway. [provided by
RefSeq].1) Ong, Y.S., et al. J. Cell Biol. 190(3):331-345(2010)
Immunogen
This SEC23IP antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 724-752 amino acids from the C-terminal region of human SEC23IP.
Western blot analysis in A549 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.