The protein encoded by this gene is found in
cytokine-stimulated endothelial cells and is thought to be
responsible for the accumulation of blood leukocytes at sites of
inflammation by mediating the adhesion of cells to the vascular
lining. It exhibits structural features such as the presence of
lectin- and EGF-like domains followed by short consensus repeat
(SCR) domains that contain 6 conserved cysteine residues. These
proteins are part of the selectin family of cell adhesion
molecules. Adhesion molecules participate in the interaction
between leukocytes and the endothelium and appear to be involved in
the pathogenesis of atherosclerosis.1) Palmer, C.N., et al. Diabetes 59(11):2945-2948(2010)
Immunogen
This TRAIL antibody is generated from rabbits immunized with a recombinant protein from the human TRAIL.
Western blot analysis in NCI-H460 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.