The protein encoded by this gene is a member of the serine
protease inhibitor (serpin) superfamily made up of proteins which
play central roles in the regulation of a wide variety of
physiological processes, including coagulation, fibrinolysis,
development, malignancy and inflammation. The gene product may have
a role in a growth-control, possibly growth-suppressing pathway
and, when impaired, may be involved in pancreatic carcinogenesis.
The protein is a member of the plasminogen activator inhibitor-1
family, a subset of the serpin superfamily whose members act as
tissue-specific tPA inhibitors. Two alternatively spliced
transcript variants encoding distinct protein isoforms have been
found for this gene.1) Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)
Immunogen
This SERPINI2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 375-401 amino acids from the C-terminal region of human SERPINI2.
Western blot analysis in MDA-MB453 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.