The protein encoded by this gene is one of the four known
components of the sarcoglycan complex, which is a subcomplex of the
dystrophin-glycoprotein complex (DGC). DGC forms a link between the
F-actin cytoskeleton and the extracellular matrix. This protein is
expressed most abundantly in skeletal and cardiac muscle. Mutations
in this gene have been associated with autosomal recessive
limb-girdle muscular dystrophy and dilated cardiomyopathy.
Alternatively spliced transcript variants encoding distinct
isoforms have been observed for this gene.1) Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Immunogen
This SGCD antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 232-261 amino acids from the C-terminal region of human SGCD.
Western blot analysis in mouse liver tissue lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.