Application
Immunohistochemistry of SIPA1L2 in human brain tissue with SIPA1L2 antibody at 5 μg/mL.Application
Immunofluorescence of SIPA1L2 in human brain tissue with SIPA1L2 antibody at 20 μg/mL.Application
Western blot analysis of SIPA1L2 in rat brain tissue lysate with SIPA1L2 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.| Product Name | SIPA1L2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | SIPA1L2 Antibody: Signal-induced proliferation associated-like protein 2 (SIPA1L2) is a member of the SIPA1 family of RapGAPs. Little is known of the role of the SIPA1L2 protein, but recent studies of SIPA indicate that its deregulation can cause myeloproliferative stem cell disorders in mice and increased metastases in human cancers. Other studies suggest SIPA1L1 may play important roles in embryo development and control of cell proliferation. Based on the amount of homology between SIPA family members, it is likely that SIPA1L2 plays a role in embryo development and cell proliferation, possibly including oncogenesis.1) Minato N and Hattori M. SPA-1 (Sipa1) and Rap signaling in leukemia and cancer metastasis. Cancer Sci.2009; 100:17-23. |
| Immunogen | SIPA1L2 antibody was raised against a 19 amino acid synthetic peptide from near the amino terminus of human SIPA1L2. The immunogen is located within the first 50 amino acids of SIPA1L2. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHC-PWB |
| SIPA1L2 antibody can be used for detection of SIPA1L2 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL. | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | SIPA1L2 |
|---|---|
| Alternative Names | SIPA1L2 Antibody: SPAL2 KIAA1389 Signal-induced proliferation-associated 1-like protein 2 SIPA1-like protein 2 |
| Sequence Similarities | 2) Cat. No. 10-301 - Human Brain Tissue Slide |
Application
Immunohistochemistry of SIPA1L2 in human brain tissue with SIPA1L2 antibody at 5 μg/mL.
Application
Immunofluorescence of SIPA1L2 in human brain tissue with SIPA1L2 antibody at 20 μg/mL.
Application
Western blot analysis of SIPA1L2 in rat brain tissue lysate with SIPA1L2 antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.| Positive Control | 1) Cat. No. 1463 - Rat Brain Tissue Lysate |
|---|---|
| Application Notes | SIPA1L2 antibody can be used for detection of SIPA1L2 by Western blot at 0.5 - 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL. |
| Form | Liquid |
|---|---|
| Storage Instructions | SIPA1L2 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | SIPA1L2 Antibody is supplied in PBS containing 0.02% sodium azide. |
