The protein encoded by this gene is a member of the
signal-regulatory-protein (SIRP) family, and also belongs to the
immunoglobulin superfamily. SIRP family members are receptor-type
transmembrane glycoproteins known to be involved in the negative
regulation of receptor tyrosine kinase-coupled signaling processes.
This protein was found to interact with TYROBP/DAP12, a protein
bearing immunoreceptor tyrosine-based activation motifs. This
protein was also reported to participate in the recruitment of
tyrosine kinase SYK. Multiple transcript variants encoding
different isoforms have been found for this gene. [provided by
RefSeq].1) Gaikwad, S., et al. Am. J. Pathol. 175(6):2528-2539(2009)
Immunogen
This SIRPB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 107-134 amino acids from the Central region of human SIRPB1.
Western blot analysis in A549 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.