This gene encodes a T cell adaptor protein, a class of
intracellular molecules with modular domains capable of recruiting
additional proteins but that exhibit no intrinsic enzymatic
activity. The encoded protein contains a unique N-terminal region
followed by a PH domain and C-terminal SH3 domain. Along with the
adhesion and degranulation-promoting adaptor protein, the encoded
protein plays a critical role in inside-out signaling by coupling
T-cell antigen receptor stimulation to the activation of integrins.1) Goode, E.L., et al. Nat. Genet. 42(10):874-879(2010)
Immunogen
This SKAP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 266-295 amino acids from the C-terminal region of human SKAP1.
Western blot analysis in MDA-MB453 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.