Application
Western blot analysis of SLC30A8 in human pancreas tissue lysate with SLC30A8 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide| Product Name | SLC30A8 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SLC30A8 Antibody: Solute carrier family 30 member 8, zinc transporter 8, ZNT8, Zn-T8 |
| Product description | SLC30A8 Antibody: SLC30A8 is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles and is expressed at a high level in the pancreas, particularly in islets of Langerhans, and co-localizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells (1). Allelic variants of SLC30A8 have been identified as major genetic risk factors for the development of Type 2 diabetes (2), but no genetic association has been found with Type 1 diabetes (3). SLC30A8 expression in -cells was found to be influenced by cytokine expression, particularly IFN-gamma and IL-1beta (4).1) Chimienti F, Devergnas S, Favier A, et al. Identification and cloning of a beta-cell-specific zinc transporter, ZnT-8, localized into insulin secretory granules. Diabetes 2004; 53:2330-7. |
| Immunogen | SLC30A8 antibody was raised against a peptide corresponding to 14 amino acids near the amino terminus of human SLC30A8. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAWB |
| SLC30A8 antibody can be used for Western blot at 1 - 2 μg/mL.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | SLC30A8 |
|---|---|
| Alternative Names | SLC30A8 Antibody: Solute carrier family 30 member 8 zinc transporter 8 ZNT8 Zn-T8 |
| Molecular Weight(MW) | Predicted: 35, 41 kDa Observed: 35, 41 kDa |
| Tissue Specificity | Two isoforms of SLC30A8 are known to exist; this antibody will detect both isoforms. This SLC30A8 antibody is predicted to not cross-react with other members of the SLC30 protein family. |
Application
Western blot analysis of SLC30A8 in human pancreas tissue lysate with SLC30A8 antibody at 1 μg/ml in (A) the absence and (B) the presence of blocking peptide| Positive Control | 1) Cat. No. 1307 - Human Pancreas Tissue Lysate |
|---|---|
| Application Notes | SLC30A8 antibody can be used for Western blot at 1 - 2 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | SLC30A8 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | SLC30A8 Antibody is supplied in PBS containing 0.02% sodium azide. |
