Application
Western blot analysis of Slc35D1 inA-20 lysate with Slc35D1 antibody at (A) 1 and (B) 2 μg/mL.| Product Name | Slc35D1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Slc35D1 Antibody: UGTREL7, KIAA0260, UGTREL7, Solute carrier family 35 member D1, UGTrel7 |
| Product description | Slc35D1 Antibody: The solute carrier family Slc35 consists of at least 17 proteins that act as nucleotide sugar transporters localized to the Golgi apparatus and endoplasmic reticulum. The role of the ER-resident Slc family member Slc35D1 is to transport both UDP-glucuronic acid and UDP-N-acetylgalactosamine. These molecules can serve as substrates for chondroitin sulfate biosynthesis and mice lacking the Slc35D1 gene developed a lethal form of skeletal dysplasia with severe shortening of limbs and facial structures. Examination of epiphyseal cartilage in these mice revealed a decreased proliferating zone with round chrondrocytes, scarce matrices, and reduced proteoglycan aggregates. Loss of function mutations in human Slc35D1 cause Schneckenbecken dysplasia, a severe skeletal dysplasia.1) Ishida N and Kawakita M. Molecular physiology and pathology of the nucleotide sugar transporter family (SLC35). Pflugers Arch.2004; 447:768-75. |
| Immunogen | Slc35D1 antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of the human Slc35D1. The immunogen is located within the first 50 amino acids of Slc35D1. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAWB |
| Slc35D1 antibody can be used for detection of Slc35D1 by Western blot at 1 - 2 μg/mL.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | SLC35D1 |
|---|---|
| Alternative Names | Slc35D1 Antibody: UGTREL7 KIAA0260 UGTREL7 Solute carrier family 35 member D1 UGTrel7 |
| Sequence Similarities | Predicted species reactivity based on immunogen sequence: Bovine: (88%), Pig: (81%) |
| Tissue Specificity | This antibody is predicted to not cross-react with the highly homologous Slc35D2. |
Application
Western blot analysis of Slc35D1 inA-20 lysate with Slc35D1 antibody at (A) 1 and (B) 2 μg/mL.| Positive Control | 1) Cat. No. 1288 - A20 Cell Lysate |
|---|---|
| Application Notes | Slc35D1 antibody can be used for detection of Slc35D1 by Western blot at 1 - 2 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | Slc35D1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | Slc35D1 Antibody is supplied in PBS containing 0.02% sodium azide. |
