Application
Immunohistochemistry staining of Slit Homolog 1 in brain cortex tissue using Slit Homolog 1 Antibody.| Product Name | Slit Homolog 1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SLIT1, KIAA0813, MEGF4, Slit (Drosophila) homolog 1, Slit homolog 1 protein, SLIT-1, SLIL1, Slit homolog 1 (Drosophila) |
| Product description | SLIT-1 (also known as KIAA0813, MEGF4, multiple epidermal growth factor-like domains 4 and Slit homolog 1 protein) is a Slit protein. This protein is a ligand for the Roundabout (Robo) receptors and acts as guidance cues in axonal migration/navigation during neural development, at the ventral midline of the neural tube. Slit1 and Slit2 are essential for midline guidance in the forebrain by acting as repulsive signals preventing inappropriate midline crossing by axons projecting from the olfactory bulb. Each SLIT gene encodes a putative secreted protein, which contains conserved protein-protein interaction domains including leucine-rich repeats and epidermal growth factor-like motifs, similar to those of the Drosophila protein. In situ hybridization studies indicated that the rat SLIT-1 mRNA was specifically expressed in the neurons of fetal and adult forebrains. This data suggests that the SLIT genes form an evolutionarily conserved group in vertebrates and invertebrates, and that the mammalian SLIT proteins may participate in the formation and maintenance of the nervous and endocrine systems by protein-protein interactions. Alternative splicing isoforms have been identified for Slit1 protein. |
| Immunogen | Slit Homolog 1 antibody was raised against amino acids 155 - 173 of Slit Homolog 1 (Mouse). |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHCWB |
| Slit Homolog 1 antibody can be used in Western Blot, and immunohistochemistry starting at 20 μg/mL.: |
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| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | SLIT1 |
|---|---|
| Alternative Names | SLIT1 KIAA0813 MEGF4 Slit (Drosophila) homolog 1 Slit homolog 1 protein SLIT-1 SLIL1 Slit homolog 1 (Drosophila) |
Application
Immunohistochemistry staining of Slit Homolog 1 in brain cortex tissue using Slit Homolog 1 Antibody.| Application Notes | Slit Homolog 1 antibody can be used in Western Blot, and immunohistochemistry starting at 20 μg/mL.: |
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| Form | Liquid |
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| Storage Instructions | Store Slit Homolog 1 antibody at 4 ˚C or -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide. |
