Application
ApplicationApplication
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Smad3 (Phospho-Ser425).| Product Name | Smad3 (phospho Ser425) Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | Smad3 encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis.1) Shi W, et al. J Cell Sci. 2007 Apr 1;120 (Pt 7): 1216-24Seong HA, et al. J Biol Chem. 2007 Apr 20;282 (16): 12272-89Wordinger RJ, et al. Invest Ophthalmol Vis Sci. 2007 Mar;48 (3): 1191-200LeClair RJ, et al. Circ Res. 2007 Mar 30;100 (6): 826-33 |
| Immunogen | Smad3 (Phospho-Ser425) antibody was raised against a peptide sequence around phosphorylation site of serine 425 (C-S-S-V-S (p) ) derived from Human Smad3. |
| Modification | p-Ser425 |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | IHC |
| , Immunohistochemistry: 1:50~1:100 | |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | SMAD3 |
|---|---|
| Alternative Names | LDS3 LDS1C MADH3 JV15-2 HSPC193 HsT17436 PTP2C SHPTP2 MAD-3 Mad3 Mothers against DPP homolog 3 |
| Molecular Weight(MW) | 52 kDa |
| Entrez Gene | 4088 |
|---|---|
| Protein Accession | NP_001138574.1 |
Application
Application
Application
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using Smad3 (Phospho-Ser425).| Application Notes | , Immunohistochemistry: 1:50~1:100 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store antibody at -20˚C for up to one year. |
| Storage Buffer | Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
