The protein encoded by SMARCB1 is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. SMARCB1 has been found to be a tumor suppressor, and mutations in it have been associated with malignant rhabdoid tumors.1) Mueller, W., et al., (2004) Neuropathol Appl Neurobiol 30 (3), 304-307.
Immunogen
Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human SMARCB1.
Key Feature
Clonality
Polyclonal
Host Species
Rabbit
SMARCB1 antibody can be used for detection of SMARCB1 by ELISA at 1:312500. SMARCB1 antibody can be used for detection of SMARCB1 by western blot at 2.0 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
SMARCB1 antibody can be used for detection of SMARCB1 by ELISA at 1:312500. SMARCB1 antibody can be used for detection of SMARCB1 by western blot at 2.0 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.
Additional Information
Form
Liquid
Storage Instructions
For short periods of storage (days) store at 4˚C. For longer periods of storage, store SMARCB1 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles.
Storage Buffer
Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 μL of distilled water. Final antibody concentration is 1 mg/mL.