The nuclear import of the spliceosomal snRNPs U1, U2, U4
and U5, is dependent on the presence of a complex nuclear
localization signal. The latter is composed of the
5'-2,2,7-terminal trimethylguanosine (m3G) cap structure of the U
snRNA and the Sm core domain. The protein encoded by this gene
interacts specifically with m3G-cap and functions as an
snRNP-specific nuclear import receptor. Alternatively spliced
transcript variants encoding the same protein have been identified
for this gene.1) Goette, M., et al. Biophys. J. 97(2):581-589(2009)
Immunogen
This SNUPN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 200-228 amino acids from the Central region of human SNUPN.
Western blot analysis in A375 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.