This gene encodes a member of the sorting nexin family.
Members of this family contain a phox (PX) domain, which is a
phosphoinositide binding domain, and are involved in intracellular
trafficking. Overexpression of this gene results in a decrease in
the processing of insulin and hepatocyte growth factor receptors to
their mature subunits. This decrease is caused by the
mislocalization of furin, the endoprotease responsible for cleavage
of insulin and hepatocyte growth factor receptors. This protein is
involved in endosomal trafficking from the plasma membrane to
recycling endosomes or the trans-Golgi network. This gene encodes
two transcript variants encoding distinct isoforms. [provided by
RefSeq].1) Venter, J.C., et al. Science 291(5507):1304-1351(2001)
Immunogen
This SNX15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 223-251 amino acids from the C-terminal region of human SNX15.
Western blot analysis in U937 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.