This gene is a member of the sclerostin family and encodes
an N-glycosylated, secreted protein with a C-terminal cystine
knot-like domain. This protein functions as a bone morphogenetic
protein (BMP) antagonist. Specifically, it directly associates with
BMPs, prohibiting them from binding their receptors, thereby
regulating BMP signaling during cellular proliferation,
differentiation, and programmed cell death.1) Barber, M.J., et al. PLoS ONE(3), E9763 (2010) :
Immunogen
This SOSTDC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 169-196 amino acids from the C-terminal region of human SOSTDC1.
Western blot analysis in mouse heart tissue lysates (35ug/lane).
Application
Western blot analysis in CEM cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.