Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency1) Yuan H, et al. Genes Dev. 1995 Nov 1;9 (21): 2635-45Muta M, et al. Genes Cells 2002 Aug;7 (8): 791-805 Tomioka M, et al. Nucleic Acids Res. 2002 Jul 15; 30 (14): 3202-3213.
Immunogen
SOX2 antibody was raised against a peptide sequence around aa.76~80 (G-A-E-W-K) derived from SOX2.