Sperm protein associated with the nucleus on the X chromosome E, Nuclear-associated protein SPAN-Xe, SPANX-E, SPANX family member E, SPANXE
Product description
Temporally regulated transcription and translation of
several testis-specific genes is required to initiate the series of
molecular and morphological changes in the male germ cell lineage
necessary for the formation of mature spermatozoa. This gene is a
member of the SPANX family of cancer/testis-associated genes, which
are located in a cluster on chromosome X. The SPANX genes encode
differentially expressed testis-specific proteins that localize to
various subcellular compartments. This particular gene encodes a
sperm protein that contains a consensus nuclear localization signal
but, although a role in spermatogenesis is suggested, the specific
function of this family member has not yet been determined.1) Hansen, S., et al. Syst Biol Reprod Med 55, 18-26 (2010) :
Immunogen
This SPANXE antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-65 amino acids from the Central region of human SPANXE.
Western blot analysis in HepG2 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.