Application
Immunohistochemistry staining of SPHK2 in cerebellum tissue using SPHK2 Antibody.| Product Name | SPHK2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SPHK2, SK-2, Sk2, Sphingosine kinase type 2, SPK-2, Sphingosine kinase 2, SPHK2L, SK 2, SPK 2 |
| Product description | Unlike the proliferative action of SPHK1, SPHK2 has been shown to possess anti-proliferative or pro-apoptotic action. SphK2 suppresses growth and enhances apoptosis, independent of activation of S1P receptors. Sequence analysis revealed that SphK2 contains a 9 amino acid motif similar to that present in Bcl2-homology domain 3 (BH3)-only proteins, a pro-apoptotic subgroup ofthe Bcl-2 family. Co-immunoprecipitation demonstrated that SphK2 interacted with Bcl-xL; however, mutation of the conserved leucine residue present in all BH3 domains only partially reduced apoptosis induced by SphK2, suggesting that the SphK2 protein possesses additional determinants important for thisfunction. |
| Immunogen | SPHK2 antibody was raised against a peptide near the N-Terminus of SPHK2 (Human) long form. |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | IHCWB |
| SPHK2 antibody can be used in ELISA, and immunohistochemistry starting at 10 μg/mL.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Gene Symbol | SPHK2 |
|---|---|
| Alternative Names | SPHK2 SK-2 Sk2 Sphingosine kinase type 2 SPK-2 Sphingosine kinase 2 SPHK2L SK 2 SPK 2 |
Application
Immunohistochemistry staining of SPHK2 in cerebellum tissue using SPHK2 Antibody.| Application Notes | SPHK2 antibody can be used in ELISA, and immunohistochemistry starting at 10 μg/mL.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store SPHK2 antibody at 4 ˚C or -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | PBS, 0.08% sodium azide. |
