Application
Immunohistochemistry staining of SPRY4 in heart tissue using SPRY4 Antibody.| Product Name | SPRY4 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | SPRY4, Protein sprouty homolog 4, Sprouty 4, Sprouty homolog 4 (Drosophila), Sprouty 4, Spry-4 |
| Product description | Sprouty-4 (also known as SPRY4) is an inhibitor of the insulin receptor and EGFR-transduced mitogen-activated protein kinase (MAPK) signaling pathway downstream of FGF and EGF receptor tyrosine kinase activation. It is positioned upstream of RAS activation and impairs the formation of active GTP-RAS. SPRY4 is widely expressed, with different isoforms. The protein consists of 322 amino acids, with a cysteine-rich region, Src homology 3 binding regions, proline-rich regions, and a PEST sequence. It is expressed predominantly in the cytoplasm. Northern results show bands across most tissues, with strongest expression in heart, brain, placenta, lung, and intestine. |
| Immunogen | SPRY4 antibody was raised against amino acids 306-322 of SPRY4 (Human). |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAIHCWB |
| SPRY4 antibody can be used in Western Blot, immunohistochemistry starting at 1:200, and immunoprecipitation.: |
|
| Species Reactivity | ChimpanzeeHuman |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | SPRY4 |
|---|---|
| Alternative Names | SPRY4 Protein sprouty homolog 4 Sprouty 4 Sprouty homolog 4 (Drosophila) Sprouty 4 Spry-4 |
Application
Immunohistochemistry staining of SPRY4 in heart tissue using SPRY4 Antibody.| Application Notes | SPRY4 antibody can be used in Western Blot, immunohistochemistry starting at 1:200, and immunoprecipitation.: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store SPRY4 antibody at 4 ˚C or -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | 0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide. |
