Somatostatin receptor type 5, SS-5-R, SS5-R, SS5R, SSTR5
Product description
Somatostatin and its related peptide cortistatin exert
multiple biological actions on normal and tumoral tissue targets by
interacting with somatostatin receptors (SSTRs). The protein
encoded by this gene is one of the SSTRs, which is a multi-pass
membrane protein and belongs to the G-protein coupled receptor 1
family. The activity of this receptor is mediated by G proteins
which inhibit adenylyl cyclase, and different regions of this
receptor molecule are required for the activation of different
signaling pathways. A mutation in this gene results in somatostatin
analog resistance. Alternatively spliced transcript variants have
been identified in this gene.1) Canzian, F., et al. Hum. Mol. Genet. 19(19):3873-3884(2010)
Immunogen
This SSTR5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 311-339 amino acids from the C-terminal region of human SSTR5.
Western blot analysis in CEM cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.