Signal transducing adapter molecule 2, STAM-2, Hrs-binding protein, STAM2, HBP
Product description
The protein encoded by this gene is closely related to
STAM, an adaptor protein involved in the downstream signaling of
cytokine receptors, both of which contain a SH3 domain and the
immunoreceptor tyrosine-based activation motif (ITAM). Similar to
STAM, this protein acts downstream of JAK kinases, and is
phosphorylated in response to cytokine stimulation. This protein
and STAM thus are thought to exhibit compensatory effects on the
signaling pathway downstream of JAK kinases upon cytokine
stimulation.1) Stuible, M., et al. J. Biol. Chem. 285(31):23899-23907(2010)
Immunogen
This STAM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 143-172 amino acids from the Central region of human STAM2.
Western blot analysis in ZR-75-1 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.