Application
Immunohistochemistry staining of STAT1 in lung tissue using STAT1 monoclonal Antibody.| Product Name | STAT1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | STAT1, ISGF-3, STAT91, CANDF7 |
| Product description | STAT1 (signal transducer and activator of transcription 1) is involved in a variety of systems including antiviral responses and interferon alpha (IFN-alpha) and gamma (IFN-gamma) signal transduction. STATs (signal transducers and activators of transcription) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STATs enter the nucleus to regulate transcription of many different genes. Among the seven STATs (Stat1, Stat2, Stat3, Stat4, Stat5a, Stat5b, and Stat6), Stat1, Stat3, Stat5a, and Stat5b have a wide activation profile. STAT1 is activated by many different ligands including IFN family (IFN-a, IFN-b, IFN-g and IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, and G-CSF), and receptor tyrosine kinases (EGF, PDGF, and CSF-1). STAT1 has two forms, the 91 kDa STAT1a and the 84 kDa STAT1b which are encoded by the same gene with splicing variant. |
| Immunogen | STAT1 monoclonal antibody was raised against amino acids 721 - 733 of STAT1 (Human). |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG2b |
| Host Species | Mouse |
| Tested Applications | IHCIPWB |
| IHC-P (5 ug/ml), IP, WB: |
|
| Species Reactivity | BatBovineDogGibbonGorillaHamsterHorseHumanMonkeyMouseOrangutanPigSheep |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | STAT1 |
|---|---|
| Alternative Names | STAT1 ISGF-3 STAT91 CANDF7 |
| Tissue Specificity | Recongizes an epitope included within amino acids 721-733 of STAT1 (signal transducer and activator of transcription 1), a 91 kDa protein. |
Application
Immunohistochemistry staining of STAT1 in lung tissue using STAT1 monoclonal Antibody.| Application Notes | IHC-P (5 ug/ml), IP, WB: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | STAT1 antibody can be stored short term 4 ˚C. For long term storage aliquot and store at -20 ˚C. As with all antibodies avoid freeze/thaw cycles. |
| Storage Buffer | PBS, 15 mM sodium azide, approx., pH 7.4. |
