Application
Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using STAT2 (Ab-690).Application
Western blot analysis of lysed extracts from HeLa cells using STAT2 (Ab-690).| Product Name | STAT2 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | P113, ISGF-3, STAT113, HYRC, HYRC1, P113 |
| Product description | STAT2 encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus.1) Fu, X. et al. (1992) Biochemistry 89, 7840-7843. Park, C. et al. (2000) Immunity 13, 795-804. Horvath, C. et al. (1996) Molecular and Cellular Biology 16, 6957-6964. Improta, T. et al. (1994) Proc. Natl. Acad. Sci. USA 91, 4776-4780. |
| Immunogen | STAT2 (Ab-690) antibody was raised against a peptide sequence around aa.688~692 (R-K-Y-L-K) derived from Human STAT2. |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | IHCWB |
| Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | STAT2 |
|---|---|
| Alternative Names | P113 ISGF-3 STAT113 HYRC HYRC1 P113 |
| Molecular Weight(MW) | 113 kDa |
| Tissue Specificity | This antibody detects endogenous level of total STAT2 protein. |
| Entrez Gene | 6773 |
|---|---|
| Protein Accession | NP_005410.1 |
Application
Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using STAT2 (Ab-690).
Application
Western blot analysis of lysed extracts from HeLa cells using STAT2 (Ab-690).| Application Notes | Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store antibody at -20˚C for up to one year. |
| Storage Buffer | Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
