Application
Western blot analysis of lysed extracts from HeLa cells untreated or treated with IFN-α using Stat2 (phospho-Tyr690).| Product Name | Stat2 (phospho Tyr690) Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | P113, ISGF-3, STAT113, MAPKAPK1A, RSK1, P113, MGC59816 |
| Product description | The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) hasbeen shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene.1) Fu X. Y, et al. Proc. Natl. Acad. Sci. U. S. A. 89:7840-7843 (1992) Yan R, et al. Nucleic Acids Res. 23:459-463 (1995) Fu X. Y. Cell 70:323-335 (1992) Sugiyama T, et al. FEBS Lett. 381:191-194 (1996) |
| Immunogen | Stat2 (phospho-Tyr690) antibody was raised against a peptide sequence around phosphorylation site of tyrosine 690 (R-K-Y (p) -L-K) derived from Human Stat2. |
| Modification | p-Tyr690 |
| Clonality | Polyclonal |
|---|---|
| Isotype | Cocktail |
| Host Species | Rabbit |
| Tested Applications | IHCWB |
| Western Blot: 1:1000: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | STAT2 |
|---|---|
| Alternative Names | P113 ISGF-3 STAT113 MAPKAPK1A RSK1 P113 MGC59816 |
| Molecular Weight(MW) | 113 kDa |
| Tissue Specificity | This antibody detects endogenous level of Stat2 only when phosphorylated at Tyrosine 690. |
| Entrez Gene | 6773 |
|---|---|
| Protein Accession | NP_005410.1 |
Application
Western blot analysis of lysed extracts from HeLa cells untreated or treated with IFN-α using Stat2 (phospho-Tyr690).| Application Notes | Western Blot: 1:1000: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store antibody at -20˚C for up to one year. |
| Storage Buffer | Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
