This gene encodes a secreted, homodimeric glycoprotein
that is expressed in a wide variety of tissues and may have
autocrine or paracrine functions. The gene contains a 5' UTR rich
in CAG trinucleotide repeats. The encoded protein contains 11
conserved cysteine residues and is phosphorylated by protein kinase
C exclusively on its serine residues. The protein may play a role
in the regulation of renal and intestinal calcium and phosphate
transport, cell metabolism, or cellular calcium/phosphate
homeostasis. Overexpression of human stanniocalcin 1 in mice
produces high serum phosphate levels, dwarfism, and increased
metabolic rate. This gene has altered expression in hepatocellular,
ovarian, and breast cancers.1) Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Immunogen
This STC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 193-221 amino acids from the C-terminal region of human STC1.
Western blot analysis in U251 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.