Application
Western blot analysis of Strumpellin in human ovary tissue lysate with Strumpellin antibody at 1 μg/mL.| Product Name | Strumpellin Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Strumpellin Antibody: RTSC, SPG8, WASH complex subunit strumpellin |
| Product description | Strumpellin Antibody: Strumpellin is a ubiquitously expressed, multi-transmembrane and spectrin-repeat-containing protein. It is named for Strumpell disease; a progressive upper-motor neurodegenerative disease termed hereditary spastic paraplegia (HSP). The Strumpellin gene maps to the eighth HSP locus (SPG8) on chromosome 8p24.13. Three families liked to this locus have mutations in the Strumpellin gene; rescue studies of zebrafish with decreased Strumpellin expression with Strumpellin mRNA containing these mutations showed impaired normal function of this protein. Recent studies suggest that Strumpellin may also be involved in protein aggregation diseases.1) Valmanis PN, Meijer IA, Reynolds A, et al. Mutations in the KIAA0196 gene at the SPG8 locus cause hereditary spastic paraplegia. Am. J. Hum. Gen. 2007; 80:152-61. |
| Immunogen | Strumpellin antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human Strumpellin. The immunogen is located within the last 50 amino acids of Strumpellin. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAWB |
| Strumpellin antibody can be used for detection of Strumpellin by Western blot at 1 μg/mL.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | KIAA0196 |
|---|---|
| Alternative Names | Strumpellin Antibody: RTSC SPG8 WASH complex subunit strumpellin |
| Tissue Specificity | Multiple isoforms of Strumpellin are known to exist. |
Application
Western blot analysis of Strumpellin in human ovary tissue lysate with Strumpellin antibody at 1 μg/mL.| Positive Control | 1) Cat. No. 1316 - Human Ovary Tissue Lysate |
|---|---|
| Application Notes | Strumpellin antibody can be used for detection of Strumpellin by Western blot at 1 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | Strumpellin antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | Strumpellin Antibody is supplied in PBS containing 0.02% sodium azide. |
