Application
Antibody is used in Western blot to detect SULT1A1 in mouse kidney tissue lysate.Application
Western blot analysis of SULT1A1 using rabbit polyclonal SULT1A1 Antibody (Y143) using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the SULT1A1 gene.| Product Name | SULT1A1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | Sulfotransferase 1A1, ST1A1, Aryl sulfotransferase 1, HAST1/HAST2, Phenol sulfotransferase 1, Phenol-sulfating phenol sulfotransferase 1, P-PST 1, ST1A3, Thermostable phenol sulfotransferase, Ts-PST, SULT1A1, STP, STP1 |
| Product description | Sulphation is a significant detoxification pathway for diverse xenobiotics, yet this modification also plays an important role in the metabolism and bioactivation of many dietary and environmental mutagens, including heterocyclic amines implicated in the pathogenesis of several cancers. A major human sulfotransferase, SULT1A1, metabolizes and/or bioactivates many endogenous compounds and is implicated in a range of cancers because of its ability to transform xenobiotics to cellular mutagens and carcinogens. Genetic polymorphisms in human sulfotransferase 1A1 SULT1A1 have a major impact on SULT1A1 enzyme activity and affect the risk for cancer development in humans. A G--->A transition at codon 213 (CGC/Arg to CAC/His) of the SULT1A1 gene has been identified (SULT1A1*2), and individuals homozygous for the His allele have a markedly lower activity and stability of this enzyme than those with the high activity SULT1A1*1 allozyme, which has been associated with protection against dietary toxins and reduced susceptibility to colorectal and breast cancers.There is an increasing incidence of SULT1A1*1 homozygosity and decreasing incidence of SULT1A1*2 homozygosity with increasing age, indicating a potential association of SULT1A1*1 allozyme(s) with protection against cell and/or tissue damage during aging. CLN3, the locus for Batten disease, maps to the same region 16p12.1-p11.2 as SULT12A1, making SULT1A1 a candidate gene for this disorder.1) Carcinogenesis 25 (5), 773-778 (2004) |
| Immunogen | This SULT1A1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 128-160 amino acids from the Central region of human SULT1A1. |
| Clonality | Polyclonal |
|---|---|
| Isotype | Ig |
| Host Species | Rabbit |
| Tested Applications | WB |
| For WB starting dilution is: 1:1000: |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Gene Symbol | SULT1A1 |
|---|---|
| Alternative Names | Sulfotransferase 1A1 ST1A1 Aryl sulfotransferase 1 HAST1/HAST2 Phenol sulfotransferase 1 Phenol-sulfating phenol sulfotransferase 1 P-PST 1 ST1A3 Thermostable phenol sulfotransferase Ts-PST SULT1A1 STP STP1 |
| Molecular Weight(MW) | 34 kDa |
| Sequence Similarities | Predicted species reactivity based on immunogen sequence: Monkey |
Application
Antibody is used in Western blot to detect SULT1A1 in mouse kidney tissue lysate.
Application
Western blot analysis of SULT1A1 using rabbit polyclonal SULT1A1 Antibody (Y143) using 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the SULT1A1 gene.| Application Notes | For WB starting dilution is: 1:1000: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | Supplied in PBS with 0.09% (W/V) sodium azide. |
