Application
Immunohistochemistry of TAB3 in human kidney tissue with TAB3 antibody at 5 μg/mL.| Product Name | TAB3 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TAB3 Antibody: NAP1, MAP3K7IP3, TGF-beta-activated kinase 1 and MAP3K7-binding protein 3, Mitogen-activated protein kinase kinase kinase 7-interacting protein 3, TAB-3 |
| Product description | TAB3 Antibody: TAB3 functions in the NF-kappaB signal transduction pathway. It and the similar and functionally redundant protein TAB2, form a ternary complex with the protein kinase TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.1) Cheung PC, Nebreda AR, and Cohen P. TAB3, a new binding partner of the protein kinase TAK1. Biochem. J. 2004; 378:27-34. |
| Immunogen | TAB3 antibody was raised against a 13 amino acid synthetic peptide near the amino terminus of human TAB3. The immunogen is located within amino acids 40 - 90 of TAB3. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIHC-P |
| TAB3 antibody can be used for detection of TAB3 by immunohistochemistry at 5 μg/mL.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | TAB3 |
|---|---|
| Alternative Names | TAB3 Antibody: NAP1 MAP3K7IP3 TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 Mitogen-activated protein kinase kinase kinase 7-interacting protein 3 TAB-3 |
| Sequence Similarities | Predicted species reactivity based on immunogen sequence: Mouse: (92%) |
| Tissue Specificity | TAB3 antibody is human specific. TAB3 antibody is predicted not to cross-react with other TAB proteins. |
Application
Immunohistochemistry of TAB3 in human kidney tissue with TAB3 antibody at 5 μg/mL.| Positive Control | 1) Cat. No. 10-401 - Human Kidney Tissue Slide |
|---|---|
| Application Notes | TAB3 antibody can be used for detection of TAB3 by immunohistochemistry at 5 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | TAB3 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | TAB3 Antibody is supplied in PBS containing 0.02% sodium azide. |
