Taste receptor type 2 member 38, T2R38, PTC bitter taste receptor, Taste receptor type 2 member 61, T2R61, TAS2R38, PTC
Product description
This gene encodes a seven-transmembrane G protein-coupled
receptor that controls the ability to taste glucosinolates, a
family of bitter-tasting compounds found in plants of the Brassica
sp. Synthetic compounds phenylthiocarbamide (PTC) and
6-n-propylthiouracil (PROP) have been identified as ligands for
this receptor and have been used to test the genetic diversity of
this gene. Although several allelic forms of this gene have been
identified worldwide, there are two predominant common forms
(taster and non-taster) found outside of Africa. These alleles
differ at three nucleotide positions resulting in amino acid
changes in the protein (A49P, A262V, and V296I) with the amino acid
combination PAV identifying the taster variant (and AVI identifying
the non-taster variant).1) Reed, D.R., et al. Hum. Mol. Genet. 19(21):4278-4285(2010)
Immunogen
This TAS2R38 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 305-332 amino acids from the C-terminal region of human TAS2R38.
Western blot analysis in 293 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.