Application
Western blot analysis of extracts from HepG2 cells (Lane 2), using Tau (Phospho-Thr534/217) Antibody. The lane on the left is treated with antigen-specific peptide.| Product Name | Tau (phospho Thr534/217) Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | MAPT, MTBT1, PHF-tau |
| Product description | Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.1) Goedert M., Proc. Natl. Acad. Sci. U.S.A. 85:4051-4055(1988). |
| Immunogen | Tau (phospho Thr534/217) antibody was raised against a peptide sequence around phosphorylation site of threonine 534/217 (L-P-T (p)-P-P) derived from Human Tau. |
| Modification | p-Thr534/217 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | WB |
| Western Blot: 1:500~1:1000: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | TAU |
|---|---|
| Alternative Names | MAPT MTBT1 PHF-tau |
| Molecular Weight(MW) | 65 kDa |
| Tissue Specificity | The antibody detects endogenous levels of Tau only when phosphorylated at threonione 534/217. |
| Entrez Gene | 4137 |
|---|---|
| Protein Accession | NP_058519.3 |
Application
Western blot analysis of extracts from HepG2 cells (Lane 2), using Tau (Phospho-Thr534/217) Antibody. The lane on the left is treated with antigen-specific peptide.| Application Notes | Western Blot: 1:500~1:1000: |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store antibody at -20˚C for up to one year. |
| Storage Buffer | Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
