TEC belongs to the Tec family
of non-receptor protein-tyrosine kinases containing a pleckstrin
homology domain. Tec family kinases are involved in the
intracellular signaling mechanisms of cytokine receptors,
lymphocyte surface antigens, heterotrimeric G-protein coupled
receptors, and integrin molecules. They are also key players in the
regulation of the immune functions. Tec kinase is an integral
component of T cell signaling and has a distinct role in T cell
activation. This gene may be associated with myelodysplastic
syndrome.1) Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)
Immunogen
This TEC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 26-55 amino acids from the N-terminal region of human TEC.
Western Blot at 1:1000 dilution + K562 whole cell lysate Lysates/proteins at 20 ug per lane.
Application
Western blot analysis in ZR-75-1 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.