Application
Immunohistochemical analysis of paraffin-embedded human brain tissue using TGF beta Receptor II (Phospho-Ser225/250) antibody (left) or the same antibody preincubated with blocking peptide (right).| Product Name | TGF beta Receptor II (phospho Ser225/250) Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TGF-betaR2, TGFR2, kinase TGF-beta-R2 |
| Product description | Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis.1) RC Tripathi, Invest. Ophthalmol. Vis. Sci., Jan 1993; 34: 260. |
| Immunogen | TGF beta Receptor II (phospho Ser225/250) antibody was raised against a peptide sequence around phosphorylation site of Serine 225/250 (D-R-S (p)-D-I) derived from Human TGF beta Receptor II. |
| Modification | p-Ser225/250 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | IHC |
| IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | TGFBR2 |
|---|---|
| Alternative Names | TGF-betaR2 TGFR2 kinase TGF-beta-R2 |
| Molecular Weight(MW) | 64 kDa |
| Tissue Specificity | The antibody detects endogenous levels of TGF beta Receptor II only when phosphorylated at serine 225/250. |
| Entrez Gene | 7048 |
|---|---|
| Protein Accession | NP_003233.4 |
Application
Immunohistochemical analysis of paraffin-embedded human brain tissue using TGF beta Receptor II (Phospho-Ser225/250) antibody (left) or the same antibody preincubated with blocking peptide (right).| Application Notes | IHC:1:50~1:200 Notes:Optimal dilutions/concentrations should be determined by the researcher. |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store antibody at -20˚C for up to one year. |
| Storage Buffer | Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
