Application
Western blot analysis of TLX1 in mouse spleen tissue lysate with TLX1 antibody at (A) 1 μg/mL and (B) 2 μg/mL.Application
Immunohistochemistry of TLX1 in human spleen tissue with TLX1 antibody at 2.5 μg/ml.| Product Name | TLX1 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TLX1 Antibody: TCL3, HOX11, TCL3, T-cell leukemia homeobox protein 1, Homeobox protein Hox-11 |
| Product description | TLX1 Antibody: The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. TLX1, also called homeobox11 (HOX11), as it is located outside of the four mammalian Hox clusters, is a DNA-binding nuclear transcription factor. TLX1 encodes a homeobox-domain containing protein and is containing a glycine and proline-rich amino terminus. TLX1 is required for maintenance of the developing spleen and cell survival. TLX1 is highly expressed in T-cell leukemia and lymphoid neoplasias as a result of translocation. TLX1-deficient mice have no spleen.1) Dear TN, Sanchez-Garcia I, and Rabbitts TH, et al. The Hox11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes. Proc. Natl. Acad. Sci. USA 1993; 90:4431-5. |
| Immunogen | TLX1 antibody was raised against a 16 amino acid peptide near the amino terminus of human TLX1. The immunogen is located within the first 50 amino acids of TLX1. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIHC-PWB |
| TLX1 antibody can be used for detection of TLX1 by Western blot at 1 - 2 μg/mL.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | TLX1 |
|---|---|
| Alternative Names | TLX1 Antibody: TCL3 HOX11 TCL3 T-cell leukemia homeobox protein 1 Homeobox protein Hox-11 |
| Molecular Weight(MW) | Predicted: 36 kDa Observed: 35 kDa |
| Sequence Similarities | 2) Cat. No. 10-901 - Human Spleen Tissue Slide |
| Tissue Specificity | Multiple isoforms of TLX1 exist due to alternative splicing events. TLX1 antibody is predicted to not cross-react with other TLX proteins. |
Application
Western blot analysis of TLX1 in mouse spleen tissue lysate with TLX1 antibody at (A) 1 μg/mL and (B) 2 μg/mL.
Application
Immunohistochemistry of TLX1 in human spleen tissue with TLX1 antibody at 2.5 μg/ml.| Positive Control | 1) Cat. No. 1406 - Mouse Spleen Tissue Lysate |
|---|---|
| Application Notes | TLX1 antibody can be used for detection of TLX1 by Western blot at 1 - 2 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | TLX1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. |
| Storage Buffer | TLX1 Antibody is supplied in PBS containing 0.02% sodium azide. |
