Application
Western blot analysis of TLX3 in human spleen tissue lysate with TLX3 antibody at (A) 0.5 and (B) 1 μg/mL.Application
Immunofluorescence of TLX3 in human spleen tissue with TLX3 antibody at 20 μg/ml.Application
Immunohistochemistry of TLX3 in human spleen tissue with TLX3 antibody at 2.5 μg/ml.| Product Name | TLX3 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TLX3 Antibody: RNX, HOX11L2, T-cell leukemia homeobox protein 3, Homeobox protein Hox-11L2 |
| Product description | TLX3 Antibody: The Hox proteins play a role in patterns of embryonic development and cellular differentiation by regulating downstream target genes. TLX3, also known as homeobox11-like1 (HOX11L2), is a DNA-binding nuclear transcription factor that is expressed in a subset of the primary sensory nervous system. TLX3, along with the related TLX1, is a selector transcription factor that promotes an excitatory glutamatergic neuronal phenotype over an inhibitory GABAergic phenotype opposing LBX1 signals during dorsal spinal cord development. Chromosomal translocations of the TLX3 gene have been shown to result in some forms of T-cell acute lymphoblastic leukemia (T-ALL).1) Dear TN, Sanchez-Garcia I, and Rabbitts TH, et al. The Hox11 gene encodes a DNA-binding nuclear transcription factor belonging to a distinct family of homeobox genes. Proc. Natl. Acad. Sci. USA 1993; 90:4431-5. |
| Immunogen | TLX3 antibody was raised against a 16 amino acid peptide near the amino terminus of human TLX3. The immunogen is located within the first 50 amino acids of TLX3. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHC-PWB |
| TLX3 antibody can be used for detection of TLX3 by Western blot at 0.5 - 1 μg/mL.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | TLX3 |
|---|---|
| Alternative Names | TLX3 Antibody: RNX HOX11L2 T-cell leukemia homeobox protein 3 Homeobox protein Hox-11L2 |
| Molecular Weight(MW) | Predicted: 32 kDa Observed: 30 kDa |
| Sequence Similarities | 2) Cat. No. 10-901 - Human Spleen Tissue Slide |
| Tissue Specificity | TLX3 antibody is predicted to not cross-react with other TLX proteins. |
Application
Western blot analysis of TLX3 in human spleen tissue lysate with TLX3 antibody at (A) 0.5 and (B) 1 μg/mL.
Application
Immunofluorescence of TLX3 in human spleen tissue with TLX3 antibody at 20 μg/ml.
Application
Immunohistochemistry of TLX3 in human spleen tissue with TLX3 antibody at 2.5 μg/ml.| Positive Control | 1) Cat. No. 1306 - Human Spleen Tissue Lysate |
|---|---|
| Application Notes | TLX3 antibody can be used for detection of TLX3 by Western blot at 0.5 - 1 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | TLX3 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. |
| Storage Buffer | TLX3 Antibody is supplied in PBS containing 0.02% sodium azide. |
