Application
Western blot analysis of TMEM106A in A-20 cell lysate with TMEM106A antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.Application
Immunofluorescence of TMEM106A in mouse brain tissue with TMEM106A antibody at 20 μg/mL.Application
Immunohistochemistry of TMEM106A in mouse brain tissue with TMEM106A antibody at 5 μg/mL.| Product Name | TMEM106A Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TMEM106A Antibody: Transmembrane protein 106A |
| Product description | TMEM106A Antibody: Transmembrane protein 106A (TMEM106A) is a single-pass transmembrane protein that is closely related to TMEM106B, a protein that is thought to be a novel risk factor for frontotemporal lobar degeneration (FTLD), a group of clinically, pathologically and genetically heterogeneous disorders associated with atrophy in the frontal lobe and temporal lobe of the brain. The actual roles of TMEM106A and TMEM106B are still undetermined; however, as TMEM106B is involved in FTLD, it is possible that TMEM106A may also be a risk factor for FTLD.1) Van Deerlin VM, Sleiman PM, Martinez-Lage M, et al. Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat. Genet. 2010; 42:234-9 |
| Immunogen | TMEM106A antibody was raised against a 14 amino acid synthetic peptide near the amino terminus of human TMEM106A. The immunogen is located within the first 50 amino acids of TMEM106A. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHC-PWB |
| TMEM106A antibody can be used for detection of TMEM106A by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 5 μg/mL.: |
|
| Species Reactivity | HumanMouse |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | TMEM106A |
|---|---|
| Alternative Names | TMEM106A Antibody: Transmembrane protein 106A |
Application
Western blot analysis of TMEM106A in A-20 cell lysate with TMEM106A antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Application
Immunofluorescence of TMEM106A in mouse brain tissue with TMEM106A antibody at 20 μg/mL.
Application
Immunohistochemistry of TMEM106A in mouse brain tissue with TMEM106A antibody at 5 μg/mL.| Positive Control | 1) Cat. No. 1288 - A20 Cell Lysate |
|---|---|
| Application Notes | TMEM106A antibody can be used for detection of TMEM106A by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 5 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | TMEM106A antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | TMEM106A Antibody is supplied in PBS containing 0.02% sodium azide. |
