Application
Western blot analysis of TMEM106B in human brain tissue lysate with TMEM106B antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.Application
Immunofluorescence of TMEM106B in human liver tissue with TMEM106A antibody at 20 μg/mL.Application
Immunohistochemistry of TMEM106B in human liver tissue with TMEM106B antibody at 2.5 μg/mL.| Product Name | TMEM106B Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TMEM106B Antibody: Transmembrane protein 106B |
| Product description | TMEM106B Antibody: Transmembrane protein 106B (TMEM106B) is a single-pass transmembrane protein that is thought to be a novel risk factor for frontotemporal lobar degeneration (FTLD), a group of clinically, pathologically and genetically heterogeneous disorders associated with atrophy in the frontal lobe and temporal lobe of the brain. The actual role of TMEM106B, and that of the closely related protein TMEM106A are still undetermined.1) Van Deerlin VM, Sleiman PM, Martinez-Lage M, et al. Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nat. Genet. 2010; 42:234-9. |
| Immunogen | TMEM106B antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human TMEM106B. The immunogen is located within the first 50 amino acids of TMEM106B. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHC-PWB |
| TMEM106B antibody can be used for detection of TMEM106B by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 2.5 μg/mL.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | TMEM106B |
|---|---|
| Alternative Names | TMEM106B Antibody: Transmembrane protein 106B |
| Molecular Weight(MW) | Predicted: 30 kDa Observed: 33 kDa |
| Sequence Similarities | 2) Cat. No. 10-201 - Human Liver Tissue Slide |
| Tissue Specificity | This TMEM106B antibody is predicted to have no cross-reactivity to TMEM106A. |
Application
Western blot analysis of TMEM106B in human brain tissue lysate with TMEM106B antibody at 1 μg/mL in (A) the absence and (B) the presence of blocking peptide.
Application
Immunofluorescence of TMEM106B in human liver tissue with TMEM106A antibody at 20 μg/mL.
Application
Immunohistochemistry of TMEM106B in human liver tissue with TMEM106B antibody at 2.5 μg/mL.| Positive Control | 1) Cat. No. 1303 - Human Brain Tissue Lysate |
|---|---|
| Application Notes | TMEM106B antibody can be used for detection of TMEM106B by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 2.5 μg/mL. For immunofluorescence start at 2.5 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | TMEM106B antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | TMEM106B Antibody is supplied in PBS containing 0.02% sodium azide. |
