Application
Antibody used in WB on Human Placenta at 0.2-1 ug/ml.| Product Name | TMEM123 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TMEM123, KCT3, PORIMIN, PORMIN |
| Product description | TMEM123 is a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. TMEM123 is proposed to function as a cell surface receptor that mediates cell death.This gene encodes a highly glycosylated transmembrane protein with a high content of threonine and serine residues in its extracellular domain, similar to a broadly defined category of proteins termed mucins. Exposure of some cell types to anti-PORIMIN (pro-oncosis receptor inducing membrane injury) antibody, crosslinks this protein on the cell surface and induces a type of cell death termed oncosis. Oncosis is distinct from apoptosis and is characterized by a loss of cell membrane integrity without DNA fragmentation. This gene product is proposed to function as a cell surface receptor that mediates cell death.1) Zhang, Z. (2004) Protein Sci. 13 (10), 2819-2824. |
| Immunogen | Antibody produced in rabbits immunized with a synthetic peptide corresponding a region of human TMEM123. |
| Clonality | Polyclonal |
|---|---|
| Host Species | Rabbit |
| Tested Applications | ELISAWB |
| TMEM123 antibody can be used for detection of TMEM123 by ELISA at 1:1562500. TMEM123 antibody can be used for detection of TMEM123 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.: |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | TMEM123 |
|---|---|
| Alternative Names | TMEM123 KCT3 PORIMIN PORMIN |
| Molecular Weight(MW) | 19 kDa |
Application
Antibody used in WB on Human Placenta at 0.2-1 ug/ml.| Positive Control | 1) Cat. No. 1309 - Human Placenta Lysate |
|---|---|
| Application Notes | TMEM123 antibody can be used for detection of TMEM123 by ELISA at 1:1562500. TMEM123 antibody can be used for detection of TMEM123 by western blot at 1 μg/mL, and HRP conjugated secondary antibody should be diluted 1:50,000 - 100,000.: |
| Form | Liquid |
|---|---|
| Storage Instructions | For short periods of storage (days) store at 4˚C. For longer periods of storage, store TMEM123 antibody at -20˚C. As with any antibody avoid repeat freeze-thaw cycles. |
| Storage Buffer | Antibody is lyophilized in PBS buffer with 2% sucrose. Add 50 μL of distilled water. Final antibody concentration is 1 mg/mL. |
