Application
Western blot analysis of TMEM184C in mouse heart tissue lysate with TMEM184C antibody at 1 μg/mL.Application
Immunofluorescence of TMEM184C in mouse heart tissue with TMEM184B antibody at 20 μg/mL.Application
Immunohistochemistry of TMEM184C in mouse heart tissue with TMEM184C antibody at 5 μg/mL.| Product Name | TMEM184C Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description | TMEM184C Antibody: Anaplastic thyroid cancer is one of the most lethal forms of cancer, but the precise carcinogenic mechanism has not been identified. TMEM184C, also known as TMEM34, was identified in a cDNA microarray analysis as being down-regulated in anaplastic thyroid cancers compared to normal thyroid tissues. TMEM184C protein expression was also lower in cell lines derived from these types of cancers compared to that of normal thyroid tissues or cell lines based on other types of thyroid cancers. Furthermore, transfection of TMEM34 into KTA2 cells led to the inhibition of cell growth, suggesting that TMEM184C might act as a tumor suppressor in anaplastic thyroid cancers.1) Akaishi J, Onda M, Okamoto J, et al. Down-regulation of an inhibitor of cell growth, transmembrane protein 34 (TMEM34), in anaplastic thyroid cancer. J. Cancer Res. Clin. Oncol.2007; 133:213-8. |
| Immunogen | TMEM184C antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human TMEM184C. The immunogen is located within amino acids 340 - 390 of TMEM184C. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAIFIHC-PWB |
| TMEM184C antibody can be used for detection of TMEM184C by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | TMEM184C |
|---|---|
| Alternative Names | TMEM184C Antibody: TMEM34 TMEM34 PRO1355 Transmembrane protein 184C Transmembrane protein 34 |
| Sequence Similarities | Predicted species reactivity based on immunogen sequence: Bovine: (87%) |
Application
Western blot analysis of TMEM184C in mouse heart tissue lysate with TMEM184C antibody at 1 μg/mL.
Application
Immunofluorescence of TMEM184C in mouse heart tissue with TMEM184B antibody at 20 μg/mL.
Application
Immunohistochemistry of TMEM184C in mouse heart tissue with TMEM184C antibody at 5 μg/mL.| Positive Control | 1) Cat. No. 1401 - Mouse Heart Tissue Lysate |
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| Application Notes | TMEM184C antibody can be used for detection of TMEM184C by Western blot at 1 μg/mL. Antibody can also be used for immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.: |
| Form | Liquid |
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| Storage Instructions | TMEM184C antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | TMEM184C Antibody is supplied in PBS containing 0.02% sodium azide. |
