The protein encoded by this gene is a member of the tumor
necrosis factor (TNF) ligand family. This protein is a ligand for
TNFRSF14, which is a member of the tumor necrosis factor receptor
superfamily, and which is also known as a herpesvirus entry
mediator (HVEM). This protein may function as a costimulatory
factor for the activation of lymphoid cells and as a deterrent to
infection by herpesvirus. This protein has been shown to stimulate
the proliferation of T cells, and trigger apoptosis of various
tumor cells. This protein is also reported to prevent tumor
necrosis factor alpha mediated apoptosis in primary hepatocyte. Two
alternatively spliced transcript variant encoding distinct isoforms
have been reported.1) Stiles, K.M., et al. J. Virol. 84(22):11646-11660(2010)
Immunogen
This TNFSF14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-94 amino acids from the Central region of human TNFSF14.
Western blot analysis in A549 cell line lysates (35ug/lane).
Application Notes
For WB starting dilution is: 1:1000:
Additional Information
Form
Liquid
Storage Instructions
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.