Application
Western blot analysis of TNPO3 in rat liver tissue lysate with TNPO3 antibody at (A) 1 and (B) 2 μg/mL.| Product Name | TNPO3 Antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Antigen Alias | TNPO3 Antibody: IPO12, TRNSR, LGMD1F, MTR10A, TRN-SR, TRN-SR2, IPO12, Transportin-3, Importin-12, Imp12 |
| Product description | TNPO3 Antibody: TNPO3 is a member of the importin beta/transportin family of nuclear import receptors and is specific for the essential splicing factors termed SR proteins, binding specifically and directly to the arginine/serine (RS)-rich domains of these proteins. Further experiments demonstrated that this interaction occurs only when these RS domains are phosphorylated. More recently, TNPO3 was identified as an HIV dependency factor (HDF) and that depletion of TNPO3 resulted in HIV inhibition after reverse transcription but before integration, suggesting that TNPO3 may be an important drug target in HIV treatment. At least three isoforms of TNPO3 are known to exist.1) Kataoka N, Bachorik JL and Dreyfuss G. Transportin-SR, a nuclear import receptor for SR proteins. J. Cell Biol.1999; 145:1145-52. |
| Immunogen | TNPO3 antibody was raised against a 18 amino acid synthetic peptide from near the amino terminus of human TNPO3. The immunogen is located within amino acids 220 - 270 of TNPO3. |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISAWB |
| TNPO3 antibody can be used for detection of TNPO3 by Western blot at 1 - 2 μg/mL.: |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | TNPO3 |
|---|---|
| Alternative Names | TNPO3 Antibody: IPO12 TRNSR LGMD1F MTR10A TRN-SR TRN-SR2 IPO12 Transportin-3 Importin-12 Imp12 |
Application
Western blot analysis of TNPO3 in rat liver tissue lysate with TNPO3 antibody at (A) 1 and (B) 2 μg/mL.| Positive Control | 1) Cat. No. 1464 - Rat Liver Tissue Lysate |
|---|---|
| Application Notes | TNPO3 antibody can be used for detection of TNPO3 by Western blot at 1 - 2 μg/mL.: |
| Form | Liquid |
|---|---|
| Storage Instructions | TNPO3 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. |
| Storage Buffer | TNPO3 Antibody is supplied in PBS containing 0.02% sodium azide. |
